Diaryloxazole and Diarylthiazolealkanoic Acids: Two Novel Series of Non-steroidal Anti-inflammatory Agents

Peptic ulcer and non-steroidal anti-inflammatory agents.

Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. There were 95 gastric ulcer and 85 duodenal ulcer p...

Non-steroidal anti-inflammatory agents and the gastrointestinal tract.

The chemistry of non-steroidal anti-inflammatory agents.

It is not possible to discuss immediately the chemistry of, and the therapeutic response to, anti-inflammatory agents which do not possess the steroidal skeleton without properly defining the terms. It is even more fundamental, but entirely in order, to make some introductory remarks concerning those small molecules, normally dubbed 'drugs', which are designed to combat diseases of major import...

Non-steroidal anti-inflammatory drugs.

P 59: Non-Steroidal Anti-Inflammatory Drugs as a Prevention of Alzheimer Disease: Risks and Benefits

Alzheimer's disease (AD) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. The exact cause of Alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. This brings in mind using non-steroidal anti-inflammatory drugs (NSAID) as treatment or prevention of the disease. ...